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A sprain in the ankle occurs when you twist, roll, or awkwardly turn your ankle. Twisting or rolling can stretch or tear the ligaments, tough bands of tissues that help hold your ankle bones together. High-intensity physical activities and accidents may cause you to twist your ankles, resulting in ankle sprains. An ankle sprain may produce swelling, bruising, tenderness, and weakness around the ankle, and you won’t be able to put weight on your foot.